![]() Although such effects are often deleterious, subtype selective spider venom peptides are showing potential to treat a range of neurological disorders, including chronic pain and epilepsy. These effects can result in modified pain responses, muscle paralysis, cardiac arrest, priapism, and numbness. Voltage-gated sodium channels (Na V) are often targeted by these peptides to allosterically promote opening or closing of the channel by binding to structural domains outside the channel pore. Spider venom-derived cysteine knot peptides are a mega-diverse class of molecules that exhibit unique pharmacological properties to modulate key membrane protein targets. Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia. ![]()
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